Not known Facts About phenobarbital sodium injection dailymed
Not known Facts About phenobarbital sodium injection dailymed
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pentobarbital will lower the level or effect of darunavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Contraindicated (one)pentobarbital will decrease the extent or effect of doravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lower the level or effect of fludrocortisone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will decrease the level or effect of diltiazem by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will minimize the extent or effect of avanafil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. For patients with ED, monitor response very carefully thanks to prospective for lessened effectiveness.
pentobarbital will reduce the level or effect of ondansetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. No dosage adjustment for ondansetron is usually recommended for patients on these drugs.
pentobarbital will lessen the level or effect of doravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will decrease the extent or effect of pioglitazone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.
pentobarbital will raise the degree or effect of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will lessen the extent or effect of tamoxifen by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will reduce the extent or effect of doxorubicin liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
As a result, as sleep drugs, the barbiturates are of minimal worth beyond short-phrase use. Barbiturates have little analgesic action at subanesthetic doses. Somewhat, in subanesthetic doses these drugs may possibly increase the reaction to agonizing stimuli. All barbiturates show anticonvulsant exercise in anesthetic doses. Nevertheless, on the drugs Within this class, only phenobarbital, mephobarbital, and metharbital happen to be clinically demonstrated to generally be effective as oral anticonvulsants in subhypnotic doses. Barbiturates are respiratory depressants. The diploma of respiratory depression is dependent upon dose. With hypnotic doses, respiratory depression made by barbiturates is analogous to that which occurs through physiologic sleep with slight minimize in blood pressure and heart price. Reports in laboratory animals have proven that barbiturates trigger reduction while in the tone and contractility in the uterus, ureters, and urinary bladder. Nonetheless, concentrations with the drugs required to produce this effect in humans are not arrived at with sedative-hypnotic doses. Barbiturates will not impair typical hepatic function, but have already been revealed to induce liver microsomal enzymes, Consequently escalating and/or altering the metabolism of barbiturates and other drugs. (See “Safeguards-Drug Interactions” section).
pentobarbital will lower the level or effect of bosentan by impacting hepatic enzyme CYP2C9/ten metabolism. Minor/Significance Unfamiliar.
pentobarbital will reduce the level or effect check here of midazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.